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High-Throughput Screening for Ligands of the HEPN Domain of Sacsin
Sacsin is a large protein implicated in the neurodevelopmental and neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), which features the loss of Purkinje neurons in the cerebellum. Although the domain architecture of sacsin suggests that it is a neuronal ch...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4569058/ https://ncbi.nlm.nih.gov/pubmed/26366743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137298 |
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