High-Throughput Screening for Ligands of the HEPN Domain of Sacsin

Sacsin is a large protein implicated in the neurodevelopmental and neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), which features the loss of Purkinje neurons in the cerebellum. Although the domain architecture of sacsin suggests that it is a neuronal ch...

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Foilsithe in:PLoS One
Main Authors: Li, Xinlu, Ménade, Marie, Kozlov, Guennadi, Hu, Zheping, Dai, Zheng, McPherson, Peter S., Brais, Bernard, Gehring, Kalle
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569058/
https://ncbi.nlm.nih.gov/pubmed/26366743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137298
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