Photoswitchable diacylglycerols enable optical control of protein translocation, PKC activity, and vesicle release

Increased levels of the second messenger lipid diacylglycerol (DAG) induce a variety of downstream signaling events including the translocation of C1 domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs, which feature a photoswitchable...

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Bibliografske podrobnosti
izdano v:Nat Chem Biol
Main Authors: Frank, James Allen, Yushchenko, Dmytro A., Hodson, David J., Lipstein, Noa, Nagpal, Jatin, Rutter, Guy A., Rhee, Jeong-Seop, Gottschalk, Alexander, Brose, Nils, Schultz, Carsten, Trauner, Dirk
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101201/
https://ncbi.nlm.nih.gov/pubmed/27454932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2141
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