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Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming

Synaptic vesicles must be primed to fusion competence before they can fuse with the plasma membrane in response to increased intracellular Ca(2+) levels. The presynaptic active zone protein Munc13-1 is essential for priming of glutamatergic synaptic vesicles in hippocampal neurons. However, a small...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Varoqueaux, Frederique, Sigler, Albrecht, Rhee, Jeong-Seop, Brose, Nils, Enk, Carsten, Reim, Kerstin, Rosenmund, Christian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2002
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC124419/
https://ncbi.nlm.nih.gov/pubmed/12070347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122623799
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