Optical control of insulin release using a photoswitchable sulfonylurea

Sulfonylureas are widely prescribed for the treatment of type 2 diabetes mellitus (T2DM). Through their actions on ATP-sensitive potassium (K(ATP)) channels, sulfonylureas boost insulin release from the pancreatic beta cell mass to restore glucose homeostasis. A limitation of these compounds is the...

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Bibliographische Detailangaben
Hauptverfasser: Broichhagen, Johannes, Schönberger, Matthias, Cork, Simon C., Frank, James A., Marchetti, Piero, Bugliani, Marco, Shapiro, A. M. James, Trapp, Stefan, Rutter, Guy A., Hodson, David J., Trauner, Dirk
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208094/
https://ncbi.nlm.nih.gov/pubmed/25311795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6116
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