The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

While menin plays an important role in preventing T-cell dysfunction, such as senescence and exhaustion, the regulatory mechanisms remain unclear. We found that menin prevents the induction of dysfunction in activated CD8 T cells by restricting the cellular metabolism. mTOR complex 1 (mTORC1) signal...

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Publicado en:Nat Commun
Main Authors: Suzuki, Junpei, Yamada, Takeshi, Inoue, Kazuki, Nabe, Shogo, Kuwahara, Makoto, Takemori, Nobuaki, Takemori, Ayako, Matsuda, Seiji, Kanoh, Makoto, Imai, Yuuki, Yasukawa, Masaki, Yamashita, Masakatsu
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098065/
https://ncbi.nlm.nih.gov/pubmed/30120246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05854-6
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