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The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis
Although CD4 T-cell senescence plays an important role in immunosenescence, the mechanism behind this process remains unclear. Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3988815/ https://ncbi.nlm.nih.gov/pubmed/24694524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4555 |
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