Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

Although Bach2 has an important role in regulating the Th2-type immune response, the underlying molecular mechanisms remain unclear. We herein demonstrate that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2–Batf complex antagonizes the recruit...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kuwahara, Makoto, Ise, Wataru, Ochi, Mizuki, Suzuki, Junpei, Kometani, Kohei, Maruyama, Saho, Izumoto, Maya, Matsumoto, Akira, Takemori, Nobuaki, Takemori, Ayako, Shinoda, Kenta, Nakayama, Toshinori, Ohara, Osamu, Yasukawa, Masaki, Sawasaki, Tatsuya, Kurosaki, Tomohiro, Yamashita, Masakatsu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025763/
https://ncbi.nlm.nih.gov/pubmed/27581382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12596
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