Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor

Exportin-1 (XPO1) controls the nucleo-cytoplasmic trafficking of several key growth regulatory and tumor suppressor proteins. Nuclear export blockade through XPO1 inhibition is a target for therapeutic inhibition in many cancers. Studies have suggested XPO1 upregulation as an indicator of poor progn...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Subhash, Vinod Vijay, Yeo, Mei Shi, Wang, Lingzhi, Tan, Shi Hui, Wong, Foong Ying, Thuya, Win Lwin, Tan, Woei Loon, Peethala, Praveen C., Soe, Mu Yar, Tan, David S. P., Padmanabhan, Nisha, Baloglu, Erkan, Shacham, Sharon, Tan, Patrick, Koeffler, H. Phillip, Yong, Wei Peng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095850/
https://ncbi.nlm.nih.gov/pubmed/30115935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30686-1
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