OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms

Naive CD4(+) T cells can be converted to Foxp3(+) T regulatory cells (Tregs) in the periphery (iTregs), where induction of Foxp3 gene expression is central to Treg differentiation. OX40 signaling is known to inhibit Foxp3 expression and Treg induction, but the underlying mechanisms remain poorly def...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Zhang, Xiaolong, Xiao, Xiang, Lan, Peixiang, Li, Junhui, Dou, Yaling, Chen, Wenhao, Ishii, Naoto, Chen, Shuqiu, Xia, Bo, Chen, Kaifu, Taparowsky, Elizabeth, Li, Xian C.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095196/
https://ncbi.nlm.nih.gov/pubmed/30021159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.052
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