OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms

Naive CD4(+) T cells can be converted to Foxp3(+) T regulatory cells (Tregs) in the periphery (iTregs), where induction of Foxp3 gene expression is central to Treg differentiation. OX40 signaling is known to inhibit Foxp3 expression and Treg induction, but the underlying mechanisms remain poorly def...

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Publicado en:Cell Rep
Autores principales: Zhang, Xiaolong, Xiao, Xiang, Lan, Peixiang, Li, Junhui, Dou, Yaling, Chen, Wenhao, Ishii, Naoto, Chen, Shuqiu, Xia, Bo, Chen, Kaifu, Taparowsky, Elizabeth, Li, Xian C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095196/
https://ncbi.nlm.nih.gov/pubmed/30021159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.052
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