GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation

Glucocorticoid-induced TNFR-related protein (GITR) is a costimulatory molecule with diverse effects on effector T cells and regulatory T cells (Tregs), but the underlying mechanism remains poorly defined. Here we demonstrate that GITR ligation subverts the induction of Foxp3(+) Tregs and directs the...

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Vydáno v:Nat Commun
Hlavní autoři: Xiao, Xiang, Shi, Xiaomin, Fan, Yihui, Zhang, Xiaolong, Wu, Minhao, Lan, Peixiang, Minze, Laurie, Fu, Yang-Xin, Ghobrial, Rafik M., Liu, Wentao, Li, Xian Chang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570275/
https://ncbi.nlm.nih.gov/pubmed/26365427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9266
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