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GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation
Glucocorticoid-induced TNFR-related protein (GITR) is a costimulatory molecule with diverse effects on effector T cells and regulatory T cells (Tregs), but the underlying mechanism remains poorly defined. Here we demonstrate that GITR ligation subverts the induction of Foxp3(+) Tregs and directs the...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4570275/ https://ncbi.nlm.nih.gov/pubmed/26365427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9266 |
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