Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC

EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin in EGFR TKI resistance has been previously reported, however, the precise mechanism by which β-catenin activation contributes to EGFR TKI resistance...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Arasada, Rajeswara Rao, Shilo, Konstantin, Yamada, Tadaaki, Zhang, Jianying, Yano, Seiji, Ghanem, Rashelle, Wang, Walter, Takeuchi, Shinji, Fukuda, Koji, Katakami, Nobuyuki, Tomii, Keisuke, Ogushi, Fumitaka, Nishioka, Yasuhiko, Talabere, Tiffany, Misra, Shrilekha, Duan, Wenrui, Fadda, Paolo, Rahman, Mohammad A., Nana-Sinkam, Patrick, Evans, Jason, Amann, Joseph, Tchekneva, Elena E., Dikov, Mikhail M., Carbone, David P.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090531/
https://ncbi.nlm.nih.gov/pubmed/30097569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05626-2
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы