Multivalent forms of the Notch ligand DLL-1 enhance antitumor T cell immunity in lung cancer and improve efficacy of EGFR targeted therapy

Activation of Notch signaling in hematopoietic cells by tumors contributes to immune escape. T cell defects in tumors can be reversed by treating tumor-bearing mice with multivalent forms of the Notch receptor ligand DLL-1, but the immunologic correlates of this effect have not been elucidated. Here...

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Publié dans:Cancer Res
Auteurs principaux: Biktasova, Asel K., Dudimah, Duafalia F., Uzhachenko, Roman V., Park, Kyungho, Akhter, Anwari, Arasada, Rajeswara R., Evans, Jason V., Novitskiy, Sergey V., Tchekneva, Elena E., Carbone, David P., Shanker, Anil, Dikov, Mikhail M
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651735/
https://ncbi.nlm.nih.gov/pubmed/26404003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1154
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