Multivalent forms of the Notch ligand DLL-1 enhance antitumor T cell immunity in lung cancer and improve efficacy of EGFR targeted therapy

Activation of Notch signaling in hematopoietic cells by tumors contributes to immune escape. T cell defects in tumors can be reversed by treating tumor-bearing mice with multivalent forms of the Notch receptor ligand DLL-1, but the immunologic correlates of this effect have not been elucidated. Here...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Res
Prif Awduron: Biktasova, Asel K., Dudimah, Duafalia F., Uzhachenko, Roman V., Park, Kyungho, Akhter, Anwari, Arasada, Rajeswara R., Evans, Jason V., Novitskiy, Sergey V., Tchekneva, Elena E., Carbone, David P., Shanker, Anil, Dikov, Mikhail M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651735/
https://ncbi.nlm.nih.gov/pubmed/26404003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1154
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