Bortezomib enhances expression of effector molecules in anti-tumor CD8(+) T lymphocytes by promoting Notch-nuclear factor-κB crosstalk

The immunosuppressive tumor microenvironment usurps host antitumor immunity by multiple mechanisms including interference with the Notch system, which is important for various metazoan cell fate decisions and hematopoietic cell differentiation and function. We observed that treatment with the protea...

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Pubblicato in:Oncotarget
Autori principali: Thounaojam, Menaka C., Dudimah, Duafalia F., Pellom, Samuel T., Uzhachenko, Roman V., Carbone, David P., Dikov, Mikhail M., Shanker, Anil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper: Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741704/
https://ncbi.nlm.nih.gov/pubmed/26431276
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