Bortezomib enhances expression of effector molecules in anti-tumor CD8(+) T lymphocytes by promoting Notch-nuclear factor-κB crosstalk

The immunosuppressive tumor microenvironment usurps host antitumor immunity by multiple mechanisms including interference with the Notch system, which is important for various metazoan cell fate decisions and hematopoietic cell differentiation and function. We observed that treatment with the protea...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Thounaojam, Menaka C., Dudimah, Duafalia F., Pellom, Samuel T., Uzhachenko, Roman V., Carbone, David P., Dikov, Mikhail M., Shanker, Anil
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
Subjects:
Research Paper: Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741704/
https://ncbi.nlm.nih.gov/pubmed/26431276
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