Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8(+)T cell antitumor function

Tumor-induced immune tolerance poses a major challenge for therapeutic interventions aimed to manage cancer. We explored approaches to overcome T-cell suppression in murine breast and kidney adenocarcinomas, and lung fibrosarcoma expressing immunogenic antigens. We observed that treatment with a rev...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Pellom, Samuel T., Dudimah, Duafalia F., Thounaojam, Menaka C., Uzhachenko, Roman V., Singhal, Ashutosh, Richmond, Ann, Shanker, Anil
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352426/
https://ncbi.nlm.nih.gov/pubmed/28052005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14365
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