Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC

EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin in EGFR TKI resistance has been previously reported, however, the precise mechanism by which β-catenin activation contributes to EGFR TKI resistance...

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Publicado no:Nat Commun
Main Authors: Arasada, Rajeswara Rao, Shilo, Konstantin, Yamada, Tadaaki, Zhang, Jianying, Yano, Seiji, Ghanem, Rashelle, Wang, Walter, Takeuchi, Shinji, Fukuda, Koji, Katakami, Nobuyuki, Tomii, Keisuke, Ogushi, Fumitaka, Nishioka, Yasuhiko, Talabere, Tiffany, Misra, Shrilekha, Duan, Wenrui, Fadda, Paolo, Rahman, Mohammad A., Nana-Sinkam, Patrick, Evans, Jason, Amann, Joseph, Tchekneva, Elena E., Dikov, Mikhail M., Carbone, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090531/
https://ncbi.nlm.nih.gov/pubmed/30097569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05626-2
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