Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC

EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin in EGFR TKI resistance has been previously reported, however, the precise mechanism by which β-catenin activation contributes to EGFR TKI resistance...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nat Commun
Autores principales: Arasada, Rajeswara Rao, Shilo, Konstantin, Yamada, Tadaaki, Zhang, Jianying, Yano, Seiji, Ghanem, Rashelle, Wang, Walter, Takeuchi, Shinji, Fukuda, Koji, Katakami, Nobuyuki, Tomii, Keisuke, Ogushi, Fumitaka, Nishioka, Yasuhiko, Talabere, Tiffany, Misra, Shrilekha, Duan, Wenrui, Fadda, Paolo, Rahman, Mohammad A., Nana-Sinkam, Patrick, Evans, Jason, Amann, Joseph, Tchekneva, Elena E., Dikov, Mikhail M., Carbone, David P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090531/
https://ncbi.nlm.nih.gov/pubmed/30097569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05626-2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares