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Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells

Recent advances in next-generation sequencing have identified novel mutations and revealed complex genetic architectures in human hematological malignancies. Moving forward, new methods to quickly generate animal models that recapitulate the complex genetics of human hematological disorders are need...

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Detalhes bibliográficos
Publicado no:Exp Hematol
Main Authors: Shi, Xiangguo, Kitano, Ayumi, Jiang, Yajian, Luu, Victor, Hoegenauer, Kevin A., Nakada, Daisuke
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6088788/
https://ncbi.nlm.nih.gov/pubmed/29751067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2018.04.009
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