Highly efficient genome editing of murine and human hematopoietic progenitor cells by CRISPR/Cas9

Our understanding of the mechanisms that regulate hematopoietic stem/progenitor cells (HSPCs) has been advanced by the ability to genetically manipulate mice; however, germline modification is time-consuming and expensive. Here we describe fast, efficient, and cost-effective methods to directly modi...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Gundry, Michael C., Brunetti, Lorenzo, Lin, Angelique, Mayle, Allison E., Kitano, Ayumi, Wagner, Dimitrios, Hsu, Joanne I., Hoegenauer, Kevin A., Rooney, Cliona, Goodell, Margaret A., Nakada, Daisuke
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087995/
https://ncbi.nlm.nih.gov/pubmed/27783956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.092
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