Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site

We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and recombinant metabotropic glutamate 1 (mGlu1) receptors. These compounds did not directly activate mGlu1 receptors but markedly potentiated agonist-stimulated responses, in...

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Autors principals: Knoflach, Frédéric, Mutel, Vincent, Jolidon, Synèse, Kew, James N. C., Malherbe, Pari, Vieira, Eric, Wichmann, Jürgen, Kemp, John A.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC60883/
https://ncbi.nlm.nih.gov/pubmed/11606768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231358298
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