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Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site
We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and recombinant metabotropic glutamate 1 (mGlu1) receptors. These compounds did not directly activate mGlu1 receptors but markedly potentiated agonist-stimulated responses, in...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The National Academy of Sciences
2001
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC60883/ https://ncbi.nlm.nih.gov/pubmed/11606768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231358298 |
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