TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis

BACKGROUND: Over the last two or three decades, the pace of development of treatments for osteosarcoma tends has been slow. Novel effective therapies for osteosarcoma are still lacking. Previously, we reported that tumor-suppressing STF cDNA 3 (TSSC3) functions as an imprinted tumor suppressor gene...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Zhao, Guo-sheng, Gao, Zi-ran, Zhang, Qiao, Tang, Xue-feng, Lv, Yang-fan, Zhang, Zhao-si, Zhang, Yuan, Tan, Qiu-lin, Peng, Dong-bin, Jiang, Dian-ming, Guo, Qiao-Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085607/
https://ncbi.nlm.nih.gov/pubmed/30092789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0856-6
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