TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis

BACKGROUND: Over the last two or three decades, the pace of development of treatments for osteosarcoma tends has been slow. Novel effective therapies for osteosarcoma are still lacking. Previously, we reported that tumor-suppressing STF cDNA 3 (TSSC3) functions as an imprinted tumor suppressor gene...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Exp Clin Cancer Res
Egile Nagusiak: Zhao, Guo-sheng, Gao, Zi-ran, Zhang, Qiao, Tang, Xue-feng, Lv, Yang-fan, Zhang, Zhao-si, Zhang, Yuan, Tan, Qiu-lin, Peng, Dong-bin, Jiang, Dian-ming, Guo, Qiao-Nan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2018
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085607/
https://ncbi.nlm.nih.gov/pubmed/30092789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0856-6
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