TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis

BACKGROUND: Over the last two or three decades, the pace of development of treatments for osteosarcoma tends has been slow. Novel effective therapies for osteosarcoma are still lacking. Previously, we reported that tumor-suppressing STF cDNA 3 (TSSC3) functions as an imprinted tumor suppressor gene...

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Dades bibliogràfiques
Publicat a:J Exp Clin Cancer Res
Autors principals: Zhao, Guo-sheng, Gao, Zi-ran, Zhang, Qiao, Tang, Xue-feng, Lv, Yang-fan, Zhang, Zhao-si, Zhang, Yuan, Tan, Qiu-lin, Peng, Dong-bin, Jiang, Dian-ming, Guo, Qiao-Nan
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085607/
https://ncbi.nlm.nih.gov/pubmed/30092789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0856-6
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