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Site-specific incorporation of selenocysteine using an expanded genetic code and palladium-mediated chemical deprotection
Selenoproteins containing the 21(st) amino acid selenocysteine (Sec) exist in all three kingdoms of life and play essential roles in human health and development. The distinct low pKa, high reactivity and redox property of Sec also afford unique routes to protein modification and engineering. Howeve...
Guardado en:
| Publicado en: | J Am Chem Soc |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6082430/ https://ncbi.nlm.nih.gov/pubmed/29984990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04603 |
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