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Site-specific incorporation of selenocysteine using an expanded genetic code and palladium-mediated chemical deprotection

Selenoproteins containing the 21(st) amino acid selenocysteine (Sec) exist in all three kingdoms of life and play essential roles in human health and development. The distinct low pKa, high reactivity and redox property of Sec also afford unique routes to protein modification and engineering. Howeve...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Am Chem Soc
Päätekijät: Liu, Jun, Zheng, Feng, Cheng, Rujin, Li, Shanshan, Rozovsky, Sharon, Wang, Qian, Wang, Lei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082430/
https://ncbi.nlm.nih.gov/pubmed/29984990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04603
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