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Site-specific incorporation of selenocysteine using an expanded genetic code and palladium-mediated chemical deprotection

Selenoproteins containing the 21(st) amino acid selenocysteine (Sec) exist in all three kingdoms of life and play essential roles in human health and development. The distinct low pKa, high reactivity and redox property of Sec also afford unique routes to protein modification and engineering. Howeve...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Liu, Jun, Zheng, Feng, Cheng, Rujin, Li, Shanshan, Rozovsky, Sharon, Wang, Qian, Wang, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082430/
https://ncbi.nlm.nih.gov/pubmed/29984990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04603
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