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Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach
The poly(ADP-ribose)polymerase (PARP) enzyme tankyrase (TNKS/ARTD5, TNKS2/ARTD6) uses its ankyrin repeat clusters (ARCs) to recognize degenerate peptide motifs in a wide range of proteins, thereby recruiting such proteins and their complexes for scaffolding and/or poly(ADP-ribosyl)ation. Here, we pr...
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| 發表在: | Methods Mol Biol |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer New York
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6082341/ https://ncbi.nlm.nih.gov/pubmed/28695526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-6993-7_28 |
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