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Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling
The poly(ADP-ribose) polymerase (PARP) Tankyrase (TNKS and TNKS2) is paramount to Wnt-β-catenin signaling and a promising therapeutic target in Wnt-dependent cancers. The pool of active β-catenin is normally limited by destruction complexes, whose assembly depends on the polymeric master scaffolding...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cell Press
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4980433/ https://ncbi.nlm.nih.gov/pubmed/27494558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.06.019 |
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