Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor

Several previous studies have demonstrated that the activity of neurotransmitters acting on ligand-gated ion channels such as the nicotinic acetylcholine receptor (nAChR) can be altered by compounds binding to allosteric modulatory sites. In the case of α7 nAChRs, both positive and negative alloster...

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Veröffentlicht in:Neuropharmacology
Hauptverfasser: Smelt, Charles L.C., Sanders, Victoria R., Newcombe, Joseph, Burt, Richard P., Sheppard, Tom D., Topf, Maya, Millar, Neil S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Pergamon Press 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078708/
https://ncbi.nlm.nih.gov/pubmed/30009834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2018.07.009
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