Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice

Neuronopathic Gaucher disease (nGD) manifests as severe neurological symptoms in patients with no effective treatment available. Ryanodine receptors (Ryrs) are a family of calcium release channels on intracellular stores. The goal of this study is to determine if Ryrs are potential targets for nGD t...

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Détails bibliographiques
Publié dans:Hum Mol Genet
Auteurs principaux: Liou, Benjamin, Peng, Yanyan, Li, Ronghua, Inskeep, Venette, Zhang, Wujuan, Quinn, Brian, Dasgupta, Nupur, Blackwood, Rachel, Setchell, Kenneth D.R., Fleming, Sheila, Grabowski, Gregory A., Marshall, John, Sun, Ying
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078635/
https://ncbi.nlm.nih.gov/pubmed/27655403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw322
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