Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice

Neuronopathic Gaucher disease (nGD) manifests as severe neurological symptoms in patients with no effective treatment available. Ryanodine receptors (Ryrs) are a family of calcium release channels on intracellular stores. The goal of this study is to determine if Ryrs are potential targets for nGD t...

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Bibliografski detalji
Izdano u:Hum Mol Genet
Glavni autori: Liou, Benjamin, Peng, Yanyan, Li, Ronghua, Inskeep, Venette, Zhang, Wujuan, Quinn, Brian, Dasgupta, Nupur, Blackwood, Rachel, Setchell, Kenneth D.R., Fleming, Sheila, Grabowski, Gregory A., Marshall, John, Sun, Ying
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078635/
https://ncbi.nlm.nih.gov/pubmed/27655403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw322
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