Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease

To study the neuronal deficits in neuronopathic Gaucher Disease (nGD), the chronological behavioral profiles and the age of onset of brain abnormalities were characterized in a chronic nGD mouse model (9V/null). Progressive accumulation of glucosylceramide (GC) and glucosylsphingosine (GS) in the br...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dai, Mei, Liou, Benjamin, Swope, Brittany, Wang, Xiaohong, Zhang, Wujuan, Inskeep, Venette, Grabowski, Gregory A., Sun, Ying, Pan, Dao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012639/
https://ncbi.nlm.nih.gov/pubmed/27598339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162367
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