Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease

To study the neuronal deficits in neuronopathic Gaucher Disease (nGD), the chronological behavioral profiles and the age of onset of brain abnormalities were characterized in a chronic nGD mouse model (9V/null). Progressive accumulation of glucosylceramide (GC) and glucosylsphingosine (GS) in the br...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Dai, Mei, Liou, Benjamin, Swope, Brittany, Wang, Xiaohong, Zhang, Wujuan, Inskeep, Venette, Grabowski, Gregory A., Sun, Ying, Pan, Dao
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012639/
https://ncbi.nlm.nih.gov/pubmed/27598339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162367
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