Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice

Neuronopathic Gaucher disease (nGD) manifests as severe neurological symptoms in patients with no effective treatment available. Ryanodine receptors (Ryrs) are a family of calcium release channels on intracellular stores. The goal of this study is to determine if Ryrs are potential targets for nGD t...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Liou, Benjamin, Peng, Yanyan, Li, Ronghua, Inskeep, Venette, Zhang, Wujuan, Quinn, Brian, Dasgupta, Nupur, Blackwood, Rachel, Setchell, Kenneth D.R., Fleming, Sheila, Grabowski, Gregory A., Marshall, John, Sun, Ying
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078635/
https://ncbi.nlm.nih.gov/pubmed/27655403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw322
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