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Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature

Regulation of autophagy by proteolytically cleaved fragments of heparan sulfate proteoglycans is a novel and current research focus in tumor biology. Endorepellin is the C-terminal angiostatic fragment of the heparan sulfate proteoglycan perlecan and induces autophagy in endothelial cells. To furthe...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Neill, Thomas, Andreuzzi, Eva, Wang, Zi-Xuan, Peiper, Stephen C., Mongiat, Maurizo, Iozzo, Renato V.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078466/
https://ncbi.nlm.nih.gov/pubmed/29921586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002934
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