Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the α2β1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2): A DUAL RECEPTOR ANTAGONISM

Endorepellin, the C-terminal module of perlecan, negatively regulates angiogenesis counter to its proangiogenic parental molecule. Endorepellin (the C-terminal domain V of perlecan) binds the α2β1 integrin on endothelial cells and triggers a signaling cascade that leads to disruption of the actin cy...

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Autori principali: Goyal, Atul, Pal, Nutan, Concannon, Matthew, Paul, Matthew, Doran, Mike, Poluzzi, Chiara, Sekiguchi, Kiyotoshi, Whitelock, John M., Neill, Thomas, Iozzo, Renato V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Glycobiology and Extracellular Matrices
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138248/
https://ncbi.nlm.nih.gov/pubmed/21596751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.243626
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