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Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways: TRANSCRIPTIONAL REPRESSION OF HYPOXIA-INDUCIBLE FACTOR 1α AND VEGFA AND CONCURRENT INHIBITION OF NUCLEAR FACTOR OF ACTIVATED T CELL 1 (NFAT1) ACTIVATION
Endorepellin, the angiostatic C-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits angiogenesis by simultaneously binding to the α2β1 integrin and the vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) on endothelial cells. This interaction triggers the down-regulation...
में बचाया:
| मुख्य लेखकों: | , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Society for Biochemistry and Molecular Biology
2012
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527941/ https://ncbi.nlm.nih.gov/pubmed/23060442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401786 |
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