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High-throughput screen, using time-resolved FRET, yields actin-binding compounds that modulate actin–myosin structure and function
We have used a novel time-resolved FRET (TR-FRET) assay to detect small-molecule modulators of actin–myosin structure and function. Actin–myosin interactions play crucial roles in the generation of cellular force and movement. Numerous mutations and post-translational modifications of actin or myosi...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6078445/ https://ncbi.nlm.nih.gov/pubmed/29866882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002702 |
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