Actin-binding compounds, previously discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle

Actin's interactions with myosin and other actin-binding proteins are essential for cellular viability in numerous cell types, including muscle. In a previous high-throughput time-resolved FRET (TR-FRET) screen, we identified a class of compounds that bind to actin and affect actomyosin structu...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Guhathakurta, Piyali, Phung, Lien A., Prochniewicz, Ewa, Lichtenberger, Sarah, Wilson, Anna, Thomas, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549046/
https://ncbi.nlm.nih.gov/pubmed/32788211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014445
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