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Manganese superoxide dismutase deficiency exacerbates the mitochondrial ROS production and oxidative damage in Chagas disease

In this study, we have investigated the effects of manganese superoxide dismutase (SOD2 or MnSOD) deficiency on mitochondrial function and oxidative stress during Chagas disease. For this, C57BL/6 wild type (WT) and MnSOD(+/-) mice were infected with Trypanosoma cruzi (Tc), and evaluated at 150 days...

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Bibliografiske detaljer
Udgivet i:PLoS Negl Trop Dis
Main Authors: Wen, Jake J., Garg, Nisha Jain
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078326/
https://ncbi.nlm.nih.gov/pubmed/30044789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006687
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