Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect

Manganese superoxide dismutase (MnSOD) is a mitochondrially localized primary antioxidant enzyme, known to be essential for the survival of aerobic life and to play important roles in tumorigenesis. Here, we show that MnSOD deficiency in skin tissues of MnSOD-heterozygous knockout (Sod2(+/−)) mice l...

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Publicado en:Oncogene
Autores principales: Xu, Yong, Miriyala, Sumitra, Fang, Fang, Bakthavatchalu, Vasudevan, Noel, Teresa, Schnell, David, Wang, Chi, St Clair, William H, St Clair, Daret K
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859767/
https://ncbi.nlm.nih.gov/pubmed/25362851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.355
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