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Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase
Retinal mitochondria become dysfunctional in diabetes and the production of superoxide radicals is increased; over-expression of MnSOD abrogates mitochondrial dysfunction and prevents the development of diabetic retinopathy. The mitochondrial DNA (mtDNA) is particularly prone to oxidative damage. Th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3025400/ https://ncbi.nlm.nih.gov/pubmed/20088710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715760903494168 |
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