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Role of Mitochondrial DNA Damage in the Development of Diabetic Retinopathy, and the Metabolic Memory Phenomenon Associated with Its Progression

Diabetic retinopathy does not halt after hyperglycemia is terminated; the retina continues to experience increased oxidative stress, suggesting a memory phenomenon. Mitochondrial DNA (mtDNA) is highly sensitive to oxidative damage. The goal is to investigate the role of mtDNA damage in the developme...

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Autores principales: Madsen–Bouterse, Sally A., Mohammad, Ghulam, Kanwar, Mamta, Kowluru, Renu A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935337/
https://ncbi.nlm.nih.gov/pubmed/20088705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2009.2932
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