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Impaired Transport of Mitochondrial Transcription Factor and the Metabolic Memory Phenomenon Associated with the Progression of Diabetic Retinopathy
Diabetes damages retinal mitochondrial DNA (mtDNA), and compromises the mtDNA transcription. In the transcription and replication of mtDNA, nuclear-encoded transcription factor A (TFAM) is considered as a key activator, and we have shown that in diabetes while retinal TFAM gene expression is increas...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3596457/ https://ncbi.nlm.nih.gov/pubmed/23255365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dmrr.2384 |
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