Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish

The noncanonical inflammasome is critical for cytosolic sensing of Gram-negative pathogens. Here, we show that bacterial infection induces caspy2 activation in zebrafish fibroblasts, which mediates pyroptosis via a caspase-5-like activity. Zebrafish caspy2 binds directly to lipopolysaccharide via th...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yang, Dahai, Zheng, Xin, Chen, Shouwen, Wang, Zhuang, Xu, Wenting, Tan, Jinchao, Hu, Tianjian, Hou, Mingyu, Wang, Wenhui, Gu, Zhaoyan, Wang, Qiyao, Zhang, Ruilin, Zhang, Yuanxing, Liu, Qin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076302/
https://ncbi.nlm.nih.gov/pubmed/30076291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04984-1
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