Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing

Inflammatory caspase-11/4/5 recognize cytosolic LPS from invading Gram-negative bacteria and induce pyroptosis and cytokine release, forming rapid innate antibacterial defenses. Since extracellular or vacuole-constrained bacteria are thought to rarely access the cytoplasm, how their LPS are exposed...

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Udgivet i:PLoS Pathog
Main Authors: Chen, Shouwen, Yang, Dahai, Wen, Ying, Jiang, Zhiwei, Zhang, Lingzhi, Jiang, Jiatiao, Chen, Yaozhen, Hu, Tianjian, Wang, Qiyao, Zhang, Yuanxing, Liu, Qin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124777/
https://ncbi.nlm.nih.gov/pubmed/30138458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007240
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