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FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1

In the rapidly developing field of targeted cancer therapy there is growing interest towards therapeutics combining two or more compounds to achieve synergistic action and minimize the chance of cancer resistance to treatment. We developed a fibroblast growth factor 2 (FGF2)-conjugate bearing two cy...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Świderska, Karolina Weronika, Szlachcic, Anna, Opaliński, Łukasz, Zakrzewska, Małgorzata, Otlewski, Jacek
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6073801/
https://ncbi.nlm.nih.gov/pubmed/30029518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19072098
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