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Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity
Fibroblast growth factor 1 (FGF1) has been shown to interact with integrin α(v)β(3) through a specific binding site, involving Arg35 residue. The FGF1 mutant (R35E) with impaired integrin binding was found to be defective in its proliferative response, although it was still able to interact with FGF...
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| Publicado en: | Cells |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6721657/ https://ncbi.nlm.nih.gov/pubmed/31443196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8080899 |
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