Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors

[Image: see text] Antibody–drug conjugates (ADCs) are a new class of anticancer therapeutics that combine the selectivity of targeted treatment, ensured by monoclonal antibodies, with the potency of the cytotoxic agent. Here, we applied an analogous approach, but instead of an antibody, we used fibr...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Sørensen, Vigdis, Sokolowska-Wedzina, Aleksandra, Lobocki, Michal, Swiderska, Karolina Weronika, Krowarsch, Daniel, Wiedlocha, Antoni, Otlewski, Jacek
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044718/
https://ncbi.nlm.nih.gov/pubmed/30023704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00116
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